It's never fun to lose an ace. But that's just what the Phillies and Angels—and the fantasy owners of Roy Halladay and Jered Weaver—are having to deal with. Who will fill in, and what chances do they have to succeed?

Two more closers—Seattle's Brandon League and the Chicago Cubs' Rafael Dolis—have been demoted from their roles, but their successors are far from clear. How do the candidates stack up?

How things have changed in St. Louis. Just a week ago, we were writing about the Cardinals perhaps having nowhere to play Allen Craig, and now Lance Berkman has joined him on the sidelines. Also out: the A's Brandon McCarthy. Who will fill these voids? In one case at least, a top prospect...

Yet another closer has been deposed, this time in Oakland, where the team is also dealing with an injury to its starting center fielder. Meanwhile, over in the National League, the Mets may be mulling a similar change, while a catcher has suffered a season-ending knee injury.

After being almost no-hit for the second time in a week, one had to figure that the Minnesota Twins would make some changes. And change they will, bringing in a new shortstop. But not all are of their choosing, as DH Justin Morneau is headed to the DL. Meanwhile, SP Liam Hendricks is reportedly heading to the minors to work out his early season struggles. Who will fill the voids, and how might they fare?

The Yankees are making a change in their starting rotation; meanwhile, a few understudies behind incumbent closers finished games successfully. But who will get the ball in the ninth going forward, and how might they fare?

Cliff Lee... Daniel Hudson... Sergio Santos... Greg Holland... What do these pitchers have in common? A little downtime in their immediate future. But who will benefit from their absences?

The Giants have been in this position before, but not quite for so long of a stretch: needing to find a fill-in for closer Brian Wilson, who is expected to miss the rest of the season. Late last season, Santiago Casilla answered the call, converting six of seven saves. But might the team do something different this time around?

What began as faint rumblings that we initially passed off as "spring-training noise" has proven to be anything but: The man getting the ball in the ninth inning for the White Sox—at least initially—would seem to be the least-skilled and least-experienced of all the candidates.

The Red Sox have finally determined who will open the season as the fourth and fifth members of their rotation. But fear not for the fantasy value of one of the runners-up, who may become the source of some early season saves.

Minnesota OF Josh Willingham will be shifted from right to left field, where he has played most often during his career, manager Ron Gardenhire announced March 25. The fallout from the move may impact the playing time of some of Willingham's OF colleagues.